Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

Karaca, Ender; Weitzer, Stefan; Pehlivan, Davut; Shiraishi, Hiroshi; Gogakos, Tasos; Hanada, Toshikatsu; Jhangiani, Shalini N; Wiszniewski, Wojciech; Withers, Marjorie; Campbell, Ian M; Erdin, Serkan; Isikay, Sedat; Franco, Luis M; Gonzaga-Jauregui, Claudia; Gambin, Tomasz; Gelowani, Violet; Hunter, Jill V; Yesil, Gozde; Koparir, Erkan; Yilmaz, Sarenur; Brown, Miguel; Briskin, Daniel; Hafner, Markus; Morozov, Pavel; Farazi, Thalia A; Bernreuther, Christian; Glatzel, Markus; Trattnig, Siegfried; Friske, Joachim; Kronnerwetter, Claudia; Bainbridge, Matthew N; Gezdirici, Alper; Seven, Mehmet; Muzny, Donna M; Boerwinkle, Eric; Ozen, Mustafa; Clausen, Tim; Tuschl, Thomas; Yuksel, Adnan; Hess, Andreas; Gibbs, Richard A; Martinez, Javier; Penninger, Josef M; Lupski, James R.

Cell ; 157(3): 636-50, 2014 Apr 24.

Artigo em Inglês | MEDLINE | ID: mdl-24766809

2.

The oxidoreductase PYROXD1 uses NAD(P)⁺ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.

Asanovic, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Józef; Sillamaa, Sirelin; Köcher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier.

Mol Cell ; 81(12): 2520-2532.e16, 2021 06 17.

Artigo em Inglês | MEDLINE | ID: mdl-33930333

3.

CLP1 links tRNA metabolism to progressive motor-neuron loss.

Hanada, Toshikatsu; Weitzer, Stefan; Mair, Barbara; Bernreuther, Christian; Wainger, Brian J; Ichida, Justin; Hanada, Reiko; Orthofer, Michael; Cronin, Shane J; Komnenovic, Vukoslav; Minis, Adi; Sato, Fuminori; Mimata, Hiromitsu; Yoshimura, Akihiko; Tamir, Ido; Rainer, Johannes; Kofler, Reinhard; Yaron, Avraham; Eggan, Kevin C; Woolf, Clifford J; Glatzel, Markus; Herbst, Ruth; Martinez, Javier; Penninger, Josef M.

Nature ; 495(7442): 474-80, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23474986

4.

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.

Mair, Barbara; Popow, Johannes; Mechtler, Karl; Weitzer, Stefan; Martinez, Javier.

Biochem Soc Trans ; 41(4): 831-7, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23863140

5.

The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.

Weitzer, Stefan; Martinez, Javier.

Nature ; 447(7141): 222-6, 2007 May 10.

Artigo em Inglês | MEDLINE | ID: mdl-17495927

6.

Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes.

Köferle, Anna; Schlattl, Andreas; Hörmann, Alexandra; Thatikonda, Venu; Popa, Alexandra; Spreitzer, Fiona; Ravichandran, Madhwesh C; Supper, Verena; Oberndorfer, Sarah; Puchner, Teresa; Wieshofer, Corinna; Corcokovic, Maja; Reiser, Christoph; Wöhrle, Simon; Popow, Johannes; Pearson, Mark; Martinez, Javier; Weitzer, Stefan; Mair, Barbara; Neumüller, Ralph A.

Cell Rep ; 39(2): 110636, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35417719

7.

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.

Sekulovski, Samoil; Devant, Pascal; Panizza, Silvia; Gogakos, Tasos; Pitiriciu, Anda; Heitmeier, Katharina; Ramsay, Ewan Phillip; Barth, Marie; Schmidt, Carla; Tuschl, Thomas; Baas, Frank; Weitzer, Stefan; Martinez, Javier; Trowitzsch, Simon.

Nat Commun ; 12(1): 5610, 2021 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-34584079

8.

Molecular architecture of the human tRNA ligase complex.

Kroupova, Alena; Ackle, Fabian; Asanovic, Igor; Weitzer, Stefan; Boneberg, Franziska M; Faini, Marco; Leitner, Alexander; Chui, Alessia; Aebersold, Ruedi; Martinez, Javier; Jinek, Martin.

Elife ; 102021 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-34854379

9.

The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature.

Karayel, Evren; Bürckstümmer, Tilmann; Bilban, Martin; Dürnberger, Gerhard; Weitzer, Stefan; Martinez, Javier; Superti-Furga, Giulio.

Eur J Immunol ; 39(7): 1929-36, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19551900

10.

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.

Pinto, Paola H; Kroupova, Alena; Schleiffer, Alexander; Mechtler, Karl; Jinek, Martin; Weitzer, Stefan; Martinez, Javier.

Science ; 369(6503): 524-530, 2020 07 31.

Artigo em Inglês | MEDLINE | ID: mdl-32732418

11.

Chromosome segregation: playing polo in prophase.

Weitzer, Stefan; Uhlmann, Frank.

Dev Cell ; 2(4): 381-2, 2002 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-11970886

12.

Polymerase Î´ deficiency causes syndromic immunodeficiency with replicative stress.

Conde, Cecilia Domínguez; Petronczki, Özlem Yüce; Baris, Safa; Willmann, Katharina L; Girardi, Enrico; Salzer, Elisabeth; Weitzer, Stefan; Ardy, Rico Chandra; Krolo, Ana; Ijspeert, Hanna; Kiykim, Ayca; Karakoc-Aydiner, Elif; Förster-Waldl, Elisabeth; Kager, Leo; Pickl, Winfried F; Superti-Furga, Giulio; Martínez, Javier; Loizou, Joanna I; Ozen, Ahmet; van der Burg, Mirjam; Boztug, Kaan.

J Clin Invest ; 129(10): 4194-4206, 2019 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-31449058

13.

A model for ATP hydrolysis-dependent binding of cohesin to DNA.

Weitzer, Stefan; Lehane, Chris; Uhlmann, Frank.

Curr Biol ; 13(22): 1930-40, 2003 Nov 11.

Artigo em Inglês | MEDLINE | ID: mdl-14614818

14.

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.

Weitzer, Stefan; Hanada, Toshikatsu; Penninger, Josef M; Martinez, Javier.

Wiley Interdiscip Rev RNA ; 6(1): 47-63, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25142875

15.

HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

Popow, Johannes; Englert, Markus; Weitzer, Stefan; Schleiffer, Alexander; Mierzwa, Beata; Mechtler, Karl; Trowitzsch, Simon; Will, Cindy L; Lührmann, Reinhard; Söll, Dieter; Martinez, Javier.

Science ; 331(6018): 760-4, 2011 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-21311021

16.

hClp1: a novel kinase revitalizes RNA metabolism.

Weitzer, Stefan; Martinez, Javier.

Cell Cycle ; 6(17): 2133-7, 2007 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-17786051

17.

In vivo analysis of cohesin architecture using FRET in the budding yeast Saccharomyces cerevisiae.

Mc Intyre, John; Muller, Eric G D; Weitzer, Stefan; Snydsman, Brian E; Davis, Trisha N; Uhlmann, Frank.

EMBO J ; 26(16): 3783-93, 2007 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-17660750

BVS Doenças Infecciosas e Parasitárias

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: